ODS columns are the most popular columns and used for separations of hydrophobic compounds. The use of ion-pair reagents allows retention and separation of acidic or basic compounds on ODS columns. However, there are several problems associated with ion-pair reagents, for example, the lack of influence of ion-pair reagents on retention, the removal of ion-pair reagents retaind on the column, the use of LC-MS, etc. Hence, TCI developed and commercialised packing materials bearing both ODS ligands capable of firmly retaining hydrophobic compounds and ion-exchange ligands capable of retaining acidic or basic compounds in 1996.
Features
ODS and Weak Anion Exchange phase.
Analytes: acidic compounds and hydrohobic compounds, nucleotide, etc.