InertSustain C18
Inertness and Durability combined in a new HPLC column

Generally, silica based columns are mechanically stable and provide high efficiencies, however, they cannot be used under alkaline conditions and their residual silanol groups tend to adsorb organic bases.
InertSustain C18 employs a radically new type of silica, in which the surface of the silica is uniquely modified, enabling precise control of the silica properties. InertSustain C18 inherits the advantages of all the current Inertsil HPLC columns (e.g., extremely low operating back pressure, superior inertness to typically any analytes, high efficiency and compatibility with a wide range of solvents), but now can be used for wide pH analysis with consistent performance from column to column and lot to lot.
It is not possible to end-cap 100 % of residual silanols using traditional chemical modification procedures.
GL Sciences studied the possibility of developing a radically new type of silica, a silica that would provide both high inertness (base deactivation) and durability at a wide range of pH.

BENEFITS
1. Introducing a Radically New Type of Silica
   The introduction of Evolved Surface Silica leads to efficient method development at a wide range of pH, creating the possibility of unique selectivity changes.
2. Superior Peak Shape with Better Resolution
   As the adsorption sites and silanol distribution are strictly controlled on the Evolved Surface Silica,
   InertSustain C18 delivers highly stable chromatograms for qualitative and quantitative analysis
   for all compounds.
3. Wide pH Compatibility and High Durability
   InertSustain C18 is highly durable to acidic and basic mobile phases and can endure from pH 1 to 10.
   Some samples require high pH for dissolution or to maintain stability.
   InertSustain C18 would be the first choice column for such applications.
4. Strict Quality Control Program results in High Reproducibility
   Since the entire manufacturing process is under the control of our factory in Japan,reliable and
   consistent performance from column to column and lot to lot can be stably supplied.
5. Unmatched Operating Back Pressure
   Due to the low operating back pressure that InertSustain C18 offers, it can still deliver low pressure even
   using high-viscosity solvents.