IAM Drug Discovery Column                                                              

IAM chromatohraphy has recently gained acceptance amoung drug discovery chemists for estimating the membrane of small molecule drugs.

This IAM technique provides superior correlation with experimentally deteremined drug permeability when compared to other chromatograhpic methods. IAM more closely mimics the interaction of analytes with biological membranes, where a combination of hydrophobic, ion pairing, and hydrogen bonding interactions are possible. The combination of interactions measured by the IAM column is known as phospholipophilicity.

These advantages have led to the development of several new IAM phases used by prediciting membrane permeability.

Column Advantages

• The IAM.PC.DD2 packing offers the following advantages:
• More Hydrophobic
• Greater Stability
• Excellent Correlation to Traditional Methods
• Intestinal Tissue Correlation