Nucleodex™                                                         

ES Industries is able to offer a chiral columns based on a cyclodextrin chiral selectors. These cyclodextrins are covalently bonded to the silica matrix via a spacer, resulting in hydrolytically stabule adsorbent. Cyclodextrins are cyclic oligosaccharides consisting of glucose units. They are formed by degradation of starch by bacillus macerans or bacillus circulans under action of cyclodextringlycosyltransferase.

Nucleodex is available in different types, Beta-OH, Alpha-PM, Beta-PM and Gamma-PM. Betacyclodextrin contains seven glucose units and cavity opening of 7.5 A. Beta-OH contains Beta-cyclodextrin with free hydroxy groups and Beta-PM contains permethylated hydroxy groups. Alphacyclodextrin contains six glucose units and a smaller opening than the Beta type. The Gamma-cyclodextrin contains eight glucose units and the larger opening than the Beta type. Nucleodex columns have been used for the chiral separation of phenols, barbiturates and steroids.