Chromegabond AquaSep                                   

• Chromatograph polar compounds with pure aqueous mobile phases
• Rapid re-equilibration with gradients
• No ion-pairing reagents required for highly polar compounds
• Extremely high carbon load

AquaSep has been developed using patented technology for use with highly aqueous mobile phases, including 100% aqueous. Our patented bonding chemistry allows the bonded C8 chains to remain fully extended in the mobile phase even under highly aqueous conditions. To obtain high aqueous stability and maximum hydrophobic interaction AquaSep relies on a specially developed silane which is bonded to ultra high purity synthetically produced spherical silica. This silane contains an ether linkage placed near the point of attachment to the silica base particle. This ether group is polar enough to allow water to penetrate and hydrate the silica surface preventing the self association of the hydrophobic C8 chains. This layer of hydration permits the maximum interaction of the C8 chains with the analytes of interest and prevents any phase collapse. AquaSep can retain highly water soluble compounds such as small organic acids, water soluble vitamins and low molecular weight polar compounds. It can eliminate the need for ion-pairing reagents.