RP 20G is produced from highly cross-linked Polystyrene-divinyl benzene (PS-DVB) spherical beads. The surface of the materials has been modified by hydrophilic coating to reduce the hydrophobicity and the small pores of these particles have been sealed to prevent the trapping of biomolecules. These supports are suitable for reversed phase analysis and purification of small polypeptides, oligonucleotides and proteins.