VertiSep™ Integral columns are made with superficially porous silica microsphere (Core-shell) technolohy. The packings consist of ultra-pure silica in solid cores and thin outer shells with uniform pores. These offer excellent kinetic properties providing stable, ultra-high resolution and faster than HPLC column with conventional packings.

VertiSep™ Integral columns are 2.6μm in particle size, very narrow particle size distribution and the higher particle density. This provides efficiency of about at least 20,000 in which comparable to sub-2μm columns.

VertiSep™ Integral particles have a solid core of 1.7μm and 450nm thick outer shell respectively. The thin outer porous shell allows rapid solute mass transfer (fast kinetics) so that mobile phase flow rate can be increased to allows for very fast separations without sacrificing resolution like sub-2μm columns.

As only the thin outer shell of core shell particle is porous. This allows less back pressure and rapid solute diffusion in and out of the thin porous shell comparing to totally porous sub-2μm particle. VertiSep™ Integral columns limit at pressure up to at least 5,000psi that are compatible with standard HPLC and LC/MS equipments.

All totally porous particles (1.8μm, 3μm, and 5μm) have an acceptable particle size distribution. However, VertiSep™ Integral core- shell particle has a narrow particle size distribution, which reduces multi-path diffusion and results in high efficiency.