HECTOR-ACD WCX (Weak Cation Exchange type)

To separate acidic compounds using normal-phase bare silica gel, the addition of acid to the solution is necessary. There is no problem with the use of a pH buffer as an agent in the case of analytical separation, but when performing preparative separation, the pH-buffering agent must be removed later in the process. As HECTOR-ACD WCX with an “immobilized-acid functional group” works just as well as a buffer, however, there is no need to add a TFA buffer.